Neurotensin

	WikiDoc Resources for Neurotensin
Articles
Most recent articles on Neurotensin Most cited articles on Neurotensin Review articles on Neurotensin Articles on Neurotensin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Neurotensin Images of Neurotensin Photos of Neurotensin Podcasts & MP3s on Neurotensin Videos on Neurotensin
Evidence Based Medicine
Cochrane Collaboration on Neurotensin Bandolier on Neurotensin TRIP on Neurotensin
Clinical Trials
Ongoing Trials on Neurotensin at Clinical Trials.gov Trial results on Neurotensin Clinical Trials on Neurotensin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Neurotensin NICE Guidance on Neurotensin NHS PRODIGY Guidance FDA on Neurotensin CDC on Neurotensin
Books
Books on Neurotensin
News
Neurotensin in the news Be alerted to news on Neurotensin News trends on Neurotensin
Commentary
Blogs on Neurotensin
Definitions
Definitions of Neurotensin
Patient Resources / Community
Patient resources on Neurotensin Discussion groups on Neurotensin Patient Handouts on Neurotensin Directions to Hospitals Treating Neurotensin Risk calculators and risk factors for Neurotensin
Healthcare Provider Resources
Symptoms of Neurotensin Causes & Risk Factors for Neurotensin Diagnostic studies for Neurotensin Treatment of Neurotensin
Continuing Medical Education (CME)
CME Programs on Neurotensin
International
Neurotensin en Espanol Neurotensin en Francais
Business
Neurotensin in the Marketplace Patents on Neurotensin
Experimental / Informatics
List of terms related to Neurotensin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. Neurotensin was first isolated from extracts of bovine hypothalamus based on its ability to cause a visible vasodilation in the exposed cutaneous regions of anesthetized rats.^[1]

Structure

The sequence of bovine neurotensin was determined to be pyroGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH.^[2] Neurotensin is synthesized as part of a 169-170 amino acid precursor protein that also contains the related neuropeptide neuromedin N.^[3]^[4] The peptide coding domains are located in tandem near the carboxyl terminal end of the precursor and are bounded and separated by paired basic amino acid (lysine-arginine) processing sites.

Clinical significance

It has been associated with colorectal cancer.^[5]

References

↑ Carraway R, Leeman SE (1973). "The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami". J. Biol. Chem. 248 (19): 6854–61. PMID 4745447.
↑ Carraway R, Leeman SE (1975). "The amino acid sequence of a hypothalamic peptide, neurotensin". J. Biol. Chem. 250 (5): 1907–11. PMID 1167549.
↑ Dobner PR, Barber DL, Villa-Komaroff L, McKiernan C (1987). "Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3516–20. doi:10.1073/pnas.84.10.3516. PMID 3472221.
↑ Kislauskis E, Bullock B, McNeil S, Dobner PR (1988). "The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences". J. Biol. Chem. 263 (10): 4963–8. PMID 2832414.
↑ Wang X, Wang Q, Ives KL, Evers BM (2006). "Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells". Clin. Cancer Res. 12 (18): 5346–55. doi:10.1158/1078-0432.CCR-06-0968. PMID 17000667.

External links

Neurotensin at the US National Library of Medicine Medical Subject Headings (MeSH)

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.

Template:SIB

de:Neurotensin it:Neurotensina

Template:WikiDoc Sources

[pmid4745447-1] Carraway R, Leeman SE (1973). "The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami". J. Biol. Chem. 248 (19): 6854–61. PMID 4745447.

[pmid1167549-2] Carraway R, Leeman SE (1975). "The amino acid sequence of a hypothalamic peptide, neurotensin". J. Biol. Chem. 250 (5): 1907–11. PMID 1167549.

[pmid3472221-3] Dobner PR, Barber DL, Villa-Komaroff L, McKiernan C (1987). "Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3516–20. doi:10.1073/pnas.84.10.3516. PMID 3472221.

[pmid2832414-4] Kislauskis E, Bullock B, McNeil S, Dobner PR (1988). "The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences". J. Biol. Chem. 263 (10): 4963–8. PMID 2832414.

[pmid17000667-5] Wang X, Wang Q, Ives KL, Evers BM (2006). "Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells". Clin. Cancer Res. 12 (18): 5346–55. doi:10.1158/1078-0432.CCR-06-0968. PMID 17000667.

[1]

[2]

[3]

[4]

[5]