Anal leakage
Anal leakage is a type of fecal incontinence that comes from eating non-digestible, artificial fats such as Olestra and from medicines that prevent the absorption of dietary fats such as Orlistat, where the fat leaks out from the rectum and stains the underpants. [1] [2] [3] [4]
Artificial fats
The fat substitute Olestra, used in some reduced-calorie foods, has been proven to cause leakage in some consumers. The United States Food and Drug Administration warning indicated that excessive consumption of Olestra could result in "loose stools." As of 2003, the FDA no longer requires this warning. [2] [4]
Medications
Orlistat (Xenical) is a diet pill that works by blocking the enzymes that digest fat. As a result, fat cannot be absorbed from the gut, and instead some fat is excreted in the feces instead of being metabolically digested, and as a result, can cause oily anal leakage. [1] [3]
References
- ↑ 1.0 1.1 "Weighing a Pill For Weight Loss". Washington Post. Retrieved 2007-07-06.
While the Food and Drug Administration (FDA) still must approve the switch, the agency often follows the advice of its experts. If it does, Orlistat (xenical) -- currently sold only by prescription -- could be available over-the-counter (OTC) later this year. But it's important to know that the weight loss that's typical for users of the drug -- 5 to 10 percent of total weight -- will be less than many dieters expect. And many consumers may be put off by the drug's significant gastrointestinal side effects, including flatulence, diarrhea and anal leakage.
- ↑ 2.0 2.1 "Frito-Lay Study: Olestra Causes "Anal Oil Leakage"". Center for Science in the Public Interest. Thursday, February 13, 1997. Retrieved 2007-07-07.
The Frito-Lay report states: "The anal oil leakage symptoms were observed in this study (3 to 9% incidence range above background), as well as other changes in elimination. ... Underwear spotting was statistically significant in one of two low level consumer groups at a 5% incidence above background." Despite those problems, the authors of the report concluded that olestra-containing snacks "should have a high potential for acceptance in the marketplace."
Check date values in:|date=(help) - ↑ 3.0 3.1 "The Word Is 'Leakage'. Accidents may happen with a new OTC diet drug". Newsweek. June 25, 2007. Retrieved 2007-06-21.
GlaxoSmithKline has a tip for people who decide to try Alli, the over-the-counter weight-loss drug it is launching with a multimillion-dollar advertising blitz—keep an extra pair of pants handy. That's because Alli, a lower-dose version of the prescription drug Xenical, could (cue the late-night talk-show hosts) make you soil your pants. But while Alli's most troublesome side effect, anal leakage, is sure to be good for a few laughs, millions of people who are desperate to take off weight may still decide the threat of an accident is worth it.
Check date values in:|date=(help) - ↑ 4.0 4.1 "Reported medical side-effects of Olestra according to Procter and Gamble studies". Center for Science in the Public Interest. Retrieved 2007-06-21.
Olestra sometimes causes underwear staining associated with "anal leakage." Olestra sometimes causes underwear staining. That phenomenon may be caused most commonly by greasy, hard-to-wipe-off fecal matter, but occasionally also from anal leakage (leakage of liquid olestra through the anal sphincter).