Ewing's sarcoma pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Michael Maddaleni, B.S.
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Ewing's sarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Ewing's sarcoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Ewing's sarcoma pathophysiology |
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Risk calculators and risk factors for Ewing's sarcoma pathophysiology |
Overview
Ewing's sarcoma is the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11.
Histology
The composition of Ewing's sarcoma consists of a homogeneous population of small round cells that have a high nuclear to cytoplasmic ratio. Also, the population of small round cells are arrayed in sheets. There is a presence of scant cytoplasms which are pale, vacuolated, and are characterized by their faded boundaries.[1] The nuclei have intense color which make them easily visible. Mitotic activity is usually low within these cells, and cytoplasmic glycogen is also usually present.
- ↑ Iwamoto Y (2007). "Diagnosis and treatment of Ewing's sarcoma". Japanese Journal of Clinical Oncology. 37 (2): 79–89. doi:10.1093/jjco/hyl142. PMID 17272319. Retrieved 2012-01-04. Unknown parameter
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