Warthin's tumor
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Warthin's tumor Microchapters |
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Treatment |
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Warthin's tumor On the Web |
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American Roentgen Ray Society Images of Warthin's tumor |
Overview
Historical Perspective
Pathophysiology
Epidemiology & Demographics
Risk Factors
Screening
Causes
Differentiating Warthin's tumor
Complications & Prognosis
Diagnosis
History and Symptoms | Physical Examination | Staging | Laboratory tests | Electrocardiogram | X Rays | CT | MRI Echocardiography or Ultrasound | Other images | Alternative diagnostics
Treatment
Medical therapy | Surgical options | Primary prevention | Secondary prevention | Financial costs | Future therapies
Epdidemiology and Demographics
The gland most likely affected is the parotid gland. Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor. Warthin's tumor is more likely to occur in older adults between 60 -70 years of age. There is a slight female predilection according to recent studies, but historically it has been associated with a strong male predilection. This change is possibly due to the tumor's association with cigarette smoking and the growing use of cigarettes in women.
Pathophysiology
The appearance of this tumor under the microscope is unique. There are cystic spaces surrounded by two uniform rows of cells with centrally placed pyknotic nuclei. The cystic spaces have epithelium referred to as papillary infoldings that protude into them. Additionally, the epithelium has lymphoid stroma with germinal center formation.
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Diagnosis
Symptoms
The tumor is slow growing and painless.
Physical Examination
The tumor usually appears in the tail of the parotid gland near the angle of the mandible. In 5 - 14% of cases, Warthin's tumor is bilateral, but the two masses usually are at different times.
Treatment
Most of these tumors are treated with surgical removal. Recurrence is rare, occurring in 6 - 12% of cases. Warthin's tumor is highly unlikely to become malignant.
References
- Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.