Palmar plantar erythrodysesthesia historical perspective

Palmar plantar erythrodysesthesia Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Palmar plantar erythrodysesthesia (PPE) is a swelling and numbness of the hands and feet that occurs with chemotherapy, usually with fluorouracil, capecitabine, cytarabine, and doxorubicin.

Historical perspective

First reported in association with chemotherapy by Zuehlke in 1974 (Zuehlke, 1974).