Parotitis pathophysiology

Parotitis Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Parotitis from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
CT or MRI
Treatment
Medical Therapy
Surgery
Primary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Parotitis pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Parotitis pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Parotitis pathophysiology
CDC on Parotitis pathophysiology
Parotitis pathophysiology in the news
Blogs on Parotitis pathophysiology
Directions to Hospitals Treating Parotitis
Risk calculators and risk factors for Parotitis pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Parotitis is an inflammatory disorder of the salivary gland, or sialadenitis. It is most commonly infectious in etiology but can be autoimmune or neoplastic.

Pathophysiology

Parotitis is a disease that occurs in debilitated patients. Dehydration and decreased salivary flow/stasis are the main risk factors for ascending infection through Stenson’s duct to the gland. Postoperative patients who are dehydrated and NPO with little salivary stimulation are at particular risk with an incidence estimated at 1 in 1000. Debilitating medical conditions such as Diabetes mellitus, renal failure, HIV and Sjögrens’s syndrome are risk factors.

Patients with Anorexia, Bulimia, CF or those with salivary ductal dilation are also at risk. Ductal dilation is found in those with high intraoral pressure such as trumpet players and glass blowers. Medications with anticholinergic properties or diuretic effects

The most common bacterial cause is S. aureus. S. pneumonia, S. pyogenes and H. influenza are also common. Less commonly gram negative rods (GNR) as well as anaerobes are found. M. tuberculosis and T. pallidum have also been reported but are usually associated with chronic, painless infection.

Viral etiologies include paramyxovirus (particularly Mumps), influenza, parainfluenza, echovirus and coxsackie. Cytomegalovirus (CMV) and adenovirus have been implicated in HIV patients.

Nonbacterial causes include Wegener’s granulomatosis and lymphoma. Cat-scratch and actinomycosis should be considered if the patient fails to respond to standard therapy. This predispose to parotitis.