M2 AML
M2 AML | |
ICD-O: | 9874/3 |
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WikiDoc Resources for M2 AML |
Articles |
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Media |
Evidence Based Medicine |
Clinical Trials |
Ongoing Trials on M2 AML at Clinical Trials.gov Clinical Trials on M2 AML at Google
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Guidelines / Policies / Govt |
US National Guidelines Clearinghouse on M2 AML
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Books |
News |
Commentary |
Definitions |
Patient Resources / Community |
Directions to Hospitals Treating M2 AML Risk calculators and risk factors for M2 AML
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Healthcare Provider Resources |
Continuing Medical Education (CME) |
International |
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Business |
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
M2 is a subtype of AML (Acute Myeloid Leukemia). This subtypeis characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes. The two different proteins that are fused together are:
- RUNX1
- ETO