Synaptophysin

synaptophysin
Identifiers
Symbol	SYP
Entrez	6855
HUGO	11506
OMIM	313475
RefSeq	NM_003179
UniProt	P08247
Other data
Locus	Chr. X p11.23-p11.22

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.

External link

• Synaptophysin at the US National Library of Medicine Medical Subject Headings (MeSH)