Paraneoplastic cerebellar degeneration

Paraneoplastic cerebellar degeneration
ICD-10	G13.0
ICD-9	334.9
DiseasesDB	33977
MeSH	D020362

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Paraneoplastic cerebellar degeneration is a paraneoplastic phenomenon associated with lung, ovarian, breast, and other cancers.

It is believed to be due to an autoimmune reaction targeted against components of the central nervous system (specifically Purkinje cells and large brain stem nuclei).

It typically presents as a subacute progressive cerebellar ataxia, both truncal and appendicular.

External links

• Antibody associated with cerebellar degeneration