Cervical dysplasia screening

Cervical dysplasia Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pap Smear

Cervical dysplasia that is seen on a Pap smear is called squamous intraepithelial lesion (SIL). These changes may be graded as:

• Low-grade (LSIL)
• High-grade (HSIL)
• Possibly cancerous (malignant)

If a Pap smear shows abnormal cells or cervical dysplasia, further testing or monitoring will be recommended:

• Follow-up Pap smears may be recommended for mild cases
• Colposcopy-directed biopsy can confirm the condition
• Cone biopsy may be done after colposcopy

Dysplasia that is seen on a biopsy of the cervix is called cervical intraepithelial neoplasia (CIN). It is grouped into three categories:

• CIN I -- mild dysplasia
• CIN II -- moderate to marked dysplasia
• CIN III -- severe dysplasia to carcinoma in situ

Some strains of human papillomavirus (HPV) are known to cause cervical cancer. An HPV DNA test can identify the high-risk types of HPV linked to such cancer. This may be done:

• As a screening test for women over age 30
• For women of any age who have a slightly abnormal Pap test result