Bubonic plague future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Michael Maddaleni, B.S.
Overview
The main investigational technique being looked into is that of a vaccine to stop any possible plague outbreaks. Currently, there is not an available vaccine against the plague, particularly the pneumonic version. This all may be changing because there has been research conducted giving promising results for a vaccine against the pneumonic plague.
Pneumonic plague vaccine
Before recently, there were attempts to make a possible vaccine from a live form of the virus. Unfortunately, the live Y.Pestis strain is genetically unstable, which does not make it suitable for a vaccination.[1] Instead of using the unstable Y.Pestis a research group decided to create a strain of the Y. pseudotuberculosis gene which shares more than 95% of its genetic identity with Y.Pestis. [1]. This gene is far more stable and it has shown promising results as a an oral vaccine for the plague. This vaccine has become a good candidate for helping stop the spread and mortality of pneumonic plague.[1]
References
- ↑ 1.0 1.1 1.2 Derbise A, Cerdà Marín A, Ave P, Blisnick T, Huerre M, Carniel E, Demeure CE (2012). "An Encapsulated Yersinia pseudotuberculosis Is a Highly Efficient Vaccine against Pneumonic Plague". PLoS Neglected Tropical Diseases. 6 (2): e1528. doi:10.1371/journal.pntd.0001528. PMC 3279354. PMID 22348169. Retrieved 2012-03-02. Unknown parameter
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