Brain tumor medical therapy
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Brain tumor Microchapters |
Overview
Although there is no generally accepted therapeutic management for primary brain tumors, a surgical attempt at tumor removal or at least cytoreduction (that is, removal of as much tumor as possible, in order to reduce the number of tumor cells available for proliferation) is considered in most cases[1]. However, due to the infiltrative nature of these lesions, tumor recurrence, even following an apparently complete surgical removal, is not uncommon. Postoperative radiotherapy and chemotherapy are integral parts of the therapeutic standard for malignant tumors. Radiotherapy may also be administered in cases of "low-grade" gliomas, when a significant tumor burden reduction could not be achieved surgically.
Chemotherapy may be used with surgery or radiation treatment. Some drugs that are used t treat Brain Cancer are: Everolimus- FDA approved - approved to treat Subependymal giant cell astrocytoma in patients who haveTuberous Sclerosis and are not able to have surgery.
Other medications used to treat primary brain tumors in children may include:
- Corticosteroids, such as dexamethasone, to reduce brain swelling
- Medicines such as urea or mannitol to reduce brain swelling and pressure
- Anticonvulsants, such as evetiracetam (Keppra), to reduce seizures
- Pain medications
- Antacids or histamine blockers to control
Comfort measures, safety measures, physical therapy, and occupational therapy may be needed to improve quality of life. Counseling, support groups, and similar measures can help people cope with the disorder.
References
- ↑ Nakamura M, Konishi N, Tsunoda S, Nakase H, Tsuzuki T, Aoki H, Sakitani H, Inui T, Sakaki T. Analysis of prognostic and survival factors related to treatment of low-grade astrocytomas in adults. Oncology 2000;58:108-16. PMID 10705237.