Tetralogy of fallot causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, M.B.B.S. [2], Keri Shafer, M.D. [3]; Atif Mohammad, M.D.; Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]
Overview
Both environmental and genetic factors appear to be involved in the development of Tetralogy of Fallot.
Embrylogy
Embryologic studies show that Tetralogy of Fallot is a result of anterior malalignment of the conal septum, resulting in the clinical combination of a ventricular septal defect (VSD), pulmonary stenosis, and an overriding aorta. Right ventricular hypertrophy is secondary to this combination of abnormalities, which causes resistance to blood flow from the right ventricle.
Potential Environmental Causes or Influences
Factors that increase the risk for this condition during pregnancy include:
- Alcoholism in the mother
- Diabetes
- Pregnancy after the age of 40
- Poor nutrition during pregnancy
- Rubella or other viral illnesses during pregnancy
Genetic Causes
- There is a high incidence of chromosomal disorders in children with Tetralogy of Fallot, such as Down syndrome and diGeorge syndrome (chromosome 22 deletions, a condition associated with heart defects, hypocalcemia, and immune deficiency).
See also
References
External links
- Information by University of Michigan Health System
- Diagram of the condition
- Information for adults with ToF from the Adult Congenital Heart Association
de:Fallot-Tetralogie it:Tetralogia di Fallot nl:Tetralogie van Fallot nn:Fallots tetrade uk:Тетрада Фалло