Eosinophilia

Eosinophilia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]

Overview

• Eosinphilia refers to a group of idiopathic, neoplastic, infectious and allergic illnesses
• Eosinphilia is associated with abnormally high number of eosinphil granulocytes in the serum and/or tissue
• Reference range: 0-450 ul

Differential Diagnosis of Causes of Eosinophilia

By Organ System

Cardiovascular	Endomyocardial fibrosis, Cholesterol embolism
Chemical / poisoning	No underlying causes
Dermatologic	Erythema multiforme, Atopic dermatitis, Dermatitis herpetiformis, Eosinophilic fasciitis, Eosinophilic pustular folliculitis, Pemphigus vulgaris, Psoriasis, Systemic lupus erythematosus, Sarcoptes scabiei
Drug Side Effect	Sulphonamides, Allopurinol, Amitriptyline, Capreomycin, Caspofungin, Chlorpropamide, Clomipramine, Daptomycin, Desipramine, Dothiepin, Doxycycline, Enfuvirtide, Etravirine, Gold salts, Granulocyte-macrophage colony stimulating factor, Hydralazine, Imipramine, Interleukin 2, Micafungin, Minocycline, Nalidixic acid, Nitrofurantoin, Nortriptyline, Olanzapine, Oxytetracycline, Pentostatin, Procarbazine, Tobacco smoking, Tryptophan, Vancomycin
Ear Nose Throat	No underlying causes
Endocrine	Adrenal cortex insufficiency
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 2, Familial eosinophilia, Kostmann disease, Omenn syndrome, Wiskott-Aldrich syndrome
Hematologic	Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma
Iatrogenic	Radiotherapy
Infectious Disease	Acanthocheilonemiasis, Alveolar hydatid disease, Ancylostoma caninum, Ancylostoma duodenale, Angiostrongyliasis, Anisakiasis, Ascariasis, Capillaria, Clonorchiasis, Coccidioidomycosis, Dicrocoelium dendriticum fluke, Dracunculiasis, Echinococcus granulosus, Fasciola hepatica, Gnathostomiasis, Heterophyiasis, Lepromatous leprosy, Loa loa filariasis, Lymphatic filariasis, Mansonelliasis, Metagonimiasis, Mycobacterium tuberculosis, Onchocerciasis, Opisthorchiasis, Paragonimiasis, Schistosoma haematobium, Schistosoma mansoni, Strongyloidiasis, Toxocariasis, Trichinella spiralis
Musculoskeletal / Ortho	Polyarteritis nodosa, Polymyositis, Rheumatoid disease
Neurologic	No underlying causes
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Simple pulmonary eosinophilia, Visceral larva migrans, Allergic bronchopulmonary aspergillosis, Extrinsic allergic alveolitis, Tropical pulmonary eosinophilia, Churg-Strauss syndrome, Bronchial asthma
Renal / Electrolyte	Interstitial nephritis
Rheum / Immune / Allergy	Eosinophilia-myalgia syndrome
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Angiolymphoid hyperplasia with eosinophilia, Eosinophilic cellulitis, Hypereosinophilic syndrome, Kimura disease

In alphabetical order

• Addison's Disease
• Advanced solid tumors
• After splenectomy
• Allergic vasculitis
• Ancylostomiasis
• Angioneurotic syndrome
• Artheroembolic diseases
• Ascariasis
• Asthma
• Churg-Strauss Syndrome
• Chronic Myelogenous Leukemia (CML)
• Chronic Renal Disease
• Contact dermatitis
• Dermatitis herpetiformis
• Dermatomyositis
• Drug exanthema
• Drugs
• Dysentery
• Echinococcosis
• Eosinophilic gastroenteritis
• Eosinophilic leukemia
• Eosinophilic pulmonary infiltrate
• Erythema infectiosum
• Erythema multiforme
• Erythema nodosum
• Exfoliative dermatitis
• Facial granuloma
• Familial eosinophilia
• Felty's Syndrome
• Fibroblastic endocarditis
• Filariasis
• Food allergy
• Generalized carcinoma
• Gonorrhea
• Graft versus host disease
• Hay fever
• Henoch-Schonlein Purpura
• Hodgkin's Lymphoma
• Hypereosinophilic Syndrome
• Hypopituitarism
• Ichthyosis
• Leprosy
• Loeffler's Endocarditis
• Liver damage in cholestasis
• Mansonelliasis
• Mastocytosis
• Measles
• Muscular spasms
• Mycosis fungoides
• Myeloproliferative disorder
• Myxedema
• Necrosis near tumors
• Neurodermatitis
• Onchocercosis
• Oxyuriasis
• Ovarial carcinoma
• Pemphigus
• Pernicious anemia
• Pityriasis rosea
• Polyarteritis Nodosa
• Polycythemia
• Psoriasis
• Quincke's Edema
• Radiation disease
• Regional enteritis
• Rheumatoid Arthritis
• Sarcoidosis
• Scabies
• Scarlet Fever
• Schistosomiasis
• Serum sickness
• Thyrotoxicosis
• Toxokarosis
• Trichinosis
• Tropical pulmonary eosinophilia
• Tuberculosis
• Ulcerative colitis
• Urticaria
• Vasculitis
• Waterhouse-Friderichsen Syndrome