Leg pain

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Common Causes

Complete Differential Diagnosis of the causes of Leg pain

(By organ system)

Cardiovascular Aortoiliac occlusive disease,Cholesterol Emboli Syndrome,Deep Vein Thrombosis,Peripheral Arterial Disease,Thrombophlebitis,Varicose veins
Chemical / poisoning No underlying causes
Dermatologic Behect's disease
Drug Side Effect Abatacept Injection,Acebutolol,Acitretin,Aldesleukin,Alendronate,Allopurinol,Amikacin Sulfate Injection,Anagrelide,Anastrozole,Aripiprazole,Atazanavir,Atenolol,Atorvastatin,Bevacizumab Injection,Bortezomib,Buspirone,Capecitabine,Celecoxib,Celiac disease,Clofarabine Injection,Clonazepam,Clopidogrel,Cortisol,Darbepoetin Alfa,Docetaxel,Epoetin Alfa Injection,Ethacrynic Acid,Etidronate,Ezetimibe,Fenofibrate,Filgrastim,Fluvastatin,Gabapentin,Galantamine,Glatiramer Injection,Ibandronate,Iloprost,Imatinib,Infliximab Injection,Interferon Alfa-2a and Alfa-2b Injection,Interferon Alfacon-1 Injection,Interferon beta-1a Intramuscular Injection,Interferon Beta-1b Injection,Interferon Gamma-1b Injection,Lamivudine,Latanoprost,Leflunomide,Letrozole,Leuprolide,Lovastatin,Methimazole,Methylergonovine,Methylprednisolone,Mifepristone,Natalizumab injection ,Ofloxacin ,Paclitaxel,Peginterferon alfa-2a,Prednisone,Pyrazinamide,Quinupristin dalfopristin,Ribavirin,Rofecoxib,Rosiglitazone,Rosuvastatin,Sunitinib ,Tadalafil ,Tamsulosin ,Telbivudine ,Temozolomide ,Terbutaline,Teriparatide,Tiotropium,Torsemide,Valganciclovir,Valsartan,Vancomycin,Vinblastine,Vincristine,Zalcitabine,Ziprasidone,Zolmitriptan,Zolpidem,
Ear Nose Throat No underlying causes
Endocrine Hyperparathyroidism,Primary hyperparathyroidism
Environmental No underlying causes
Gastroenterologic Ulcerative colitis
Genetic Fairbanks disease,Familial Mediterranean fever,Mitochondrial trifunctional protein deficiency,Osteogenesis imperfecta,Hereditary multiple exostoses,Recessive multiple epiphyseal dysplasia,Farber disease
Hematologic Erdheim-Chester disease,Leukemia,Lymphangiomatosis,Multiple myeloma,Phlebitis,Phlegmasia cerulea dolens,Thrombocytosis,Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Cholesterol Embolism
Iatrogenic No underlying causes
Infectious Disease

Bacterial : Cellulitis,Q Fever,Lassa Fever,Lemierre's Syndrome

Viral : Parvovirus,Poliomyelitis,Rocky Mountain spotted fever,Acquired Immune Deficiency Syndrome,Coxsackie B

Musculoskeletal / Ortho Athlete's foot,Baker's cyst,Bone tumor,Buerger's disease,Chondroblastoma,Chondromalacia patellae,Chondrosarcoma,Gout,Hereditary multiple exostoses,Ledderhose's disease,Legg-Calve-Perthes syndrome,Morton's toe,Myofascial Pain Syndrome,Myositis ossificans,Osteochondrosis,Paget's disease of bone,Pes anserinus (leg),Pigmented villonodular synovitis,Prepatellar bursitis,Recessive multiple epiphyseal dysplasia,Retropatellar Pain Syndrome,Sciatica,Synovial osteochondromatosis,Tenosynovitis,Erythromelagia,Ewing's sarcoma,Giant cell tumor of bone,Osteoporosis,Still's disease,Fairbanks disease,Osteogenesis imperfecta
Neurologic Amyotrophic Lateral Sclerosis,Anterior spinal artery syndrome,Erythromelagia,Meralgia paraesthetica,Peripheral Neuropathy
Nutritional / Metabolic Acute Intermittent Porphyria,Farber disease,Glycogen storage disease type V,Hypercalcemia,Mucopolysaccharidosis,Osteomalacia,Hypocalcemia,Hypokalemia,Hyponatremia
Obstetric/Gynecologic No underlying causes
Oncologic Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Ewing's sarcoma,Giant cell tumor of bone,Osteochondroma,Osteoma,Osteosarcoma,Leukemia,Lymphangiomatosis,Chondroblastoma,Chondrosarcoma
Opthalmologic Behect's disease
Overdose / Toxicity No underlying causes
Psychiatric Pain disorder
Pulmonary No underlying causes
Renal / Electrolyte Hypercalcemia
Rheum / Immune / Allergy

Rheumatology : Ankylosing Spondylitis,Behcet's disease,Caplan's Syndrome,Fibromyalgia,Osteoarthritis,Osteoporosis,Polymyalgia Rheumatica,Rheumatoid arthritis,Still's disease, Gout

Immunology : Systemic lupus erythematosus,Ulcerative colitis,Vasculitis,Graft-versus-host disease,Familial Mediterranean fever

Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Phantom pain


(In alphabetical order):

  1. Abatacept Injection
  2. Acebutolol
  3. Acitretin
  4. Acquired Immune Deficiency Syndrome
  5. Acute Intermittent Porphyria
  6. Acute lymphoblastic leukemia
  7. Acute myeloid leukemia
  8. Acute promyelocytic leukemia
  9. Aldesleukin
  10. Alendronate
  11. Allopurinol
  12. Amikacin Sulfate Injection
  13. Amyotrophic Lateral Sclerosis
  14. Anagrelide
  15. Anastrozole
  16. Ankylosing Spondylitis
  17. Anterior spinal artery syndrome
  18. Aortoiliac occlusive disease
  19. Aripiprazole
  20. Atazanavir
  21. Atenolol
  22. Athlete's foot
  23. Atorvastatin
  24. Baker's cyst
  25. Behcet's disease
  26. Bevacizumab Injection
  27. Bone tumor
  28. Bortezomib
  29. Buerger's disease
  30. Buspirone
  31. Capecitabine
  32. Caplan's Syndrome
  33. Celecoxib
  34. Celiac disease
  35. Cellulitis
  36. Cholesterol Emboli Syndrome
  37. Chondroblastoma
  38. Chondromalacia patellae
  39. Chondrosarcoma
  40. Clofarabine Injection
  41. Clonazepam
  42. Clopidogrel
  43. Cortisol
  44. Darbepoetin Alfa Injection
  45. Deep Vein Thrombosis
  46. Docetaxel
  47. Epoetin Alfa Injection
  48. Erdheim-Chester disease
  49. Erythromelagia
  50. Ethacrynic Acid
  51. Etidronate
  52. Ewing's sarcoma
  53. Ezetimibe
  54. Fairbanks disease
  55. Familial Mediterranean fever
  56. Farber disease
  57. Fenofibrate
  58. Fibromyalgia
  59. Filgrastim
  60. Fluvastatin
  61. Gabapentin
  62. Galantamine
  63. Giant cell tumor of bone
  64. Glatiramer Injection
  65. Glycogen storage disease type V
  66. Gout
  67. Graft-versus-host disease
  68. Hereditary multiple exostoses
  69. Hypercalcemia
  70. Hypercalcemia
  71. Hyperparathyroidism
  72. Ibandronate
  73. Iloprost
  74. Imatinib
  75. Infliximab Injection
  76. Interferon Alfa-2a and Alfa-2b Injection
  77. Interferon Alfacon-1 Injection
  78. Interferon beta-1a Intramuscular Injection
  79. Interferon Beta-1b Injection
  80. Interferon Gamma-1b Injection
  81. Lamivudine
  82. Lassa Fever
  83. Latanoprost
  84. Ledderhose's disease
  85. Leflunomide
  86. Legg-Calve-Perthes syndrome
  87. Lemierre's Syndrome
  88. Letrozole
  89. Leukemia
  90. Leuprolide
  91. Lovastatin
  92. Lymphangiomatosis
  93. Meralgia paraesthetica
  94. Methimazole
  95. Methylergonovine Oral
  96. Methylprednisolone Oral
  97. Mifepristone
  98. Mitochondrial trifunctional protein deficiency
  99. Morton's toe
  100. Mucopolysaccharidosis
  101. Multiple myeloma
  102. Myofascial Pain Syndrome
  103. Myositis ossificans
  104. Natalizumab injection
  105. Ofloxacin
  106. Osteoarthritis
  107. Osteochondroma
  108. Osteochondrosis
  109. Osteogenesis imperfecta
  110. Osteoma
  111. Osteomalacia
  112. Osteoporosis
  113. Osteosarcoma
  114. Paclitaxel
  115. Paget's disease of bone
  116. Pain disorder
  117. Parvovirus
  118. Peginterferon alfa-2a
  119. Peripheral Arterial Disease
  120. Peripheral Neuropathy
  121. Pes anserinus (leg)
  122. Phantom pain
  123. Phlebitis
  124. Phlegmasia cerulea dolens
  125. Pigmented villonodular synovitis
  126. Poliomyelitis
  127. Polymyalgia Rheumatica
  128. Prednisone
  129. Prepatellar bursitis
  130. Primary hyperparathyroidism
  131. Pyrazinamide
  132. Q Fever
  133. Quinupristin and dalfopristin injection
  134. Recessive multiple epiphyseal dysplasia
  135. Retropatellar Pain Syndrome
  136. Rheumatoid arthritis
  137. Ribavirin
  138. Rocky Mountain spotted fever
  139. Rofecoxib
  140. Rosiglitazone
  141. Rosuvastatin
  142. Sciatica
  143. Still's disease
  144. Sunitinib
  145. Synovial osteochondromatosis
  146. Systemic lupus erythematosus
  147. Tadalafil
  148. Tamsulosin
  149. Telbivudine
  150. Temozolomide
  151. Tenosynovitis
  152. Terbutaline
  153. Teriparatide (rDNA origin) Injection
  154. Thrombocytosis
  155. Thrombophlebitis
  156. Tiotropium Oral Inhalation
  157. Torsemide Injection
  158. Ulcerative colitis
  159. Valganciclovir
  160. Valsartan
  161. Vancomycin
  162. Varicose veins
  163. Vasculitis
  164. Vinblastine
  165. Vincristine
  166. Zalcitabine
  167. Ziprasidone
  168. Zolmitriptan Nasal
  169. Zolpidem

[1] [2]

References

  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

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