Renal cell carcinoma risk factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Risk factors
A history of smoking greatly increases the risk for developing renal cell carcinoma.
Genetic risk factors
Some people may also have inherited an increased risk to develop renal cell carcinoma, and a family history of kidney cancer increases the risk. People with von Hippel-Lindau disease, a hereditary disease that also affects the capillaries of the brain, commonly also develop renal cell carcinoma.
Autosomal dominant conditions
- Birt-Hogg-Dube syndrome
- Hereditary leiomyomatosis and renal cell cancer
- Hereditary nonpolyposis colorectal cancer
- von Hippel-Lindau syndrome
Other associated genes include TRC8, OGG1, HNF1A, HNF1B, TFE3, RCCP3, and RCC17.