Cirrhosis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Overview

Differential Diagnosis	Useful Findings
Alcoholic cirrhosis	History EtOH, AST/ALT > 2
Chronic Hepatits C Virus (HCV)	HCV AB
Primary Biliary Cirrhosis (PBC)	Elevated alk phos, AMA+
Primary sclerosing cholangitis	History inflammatory bowel disease (IBD), ANA or ASMA or P-ANCA+
Autoimmune hepatitis	Hypergammaglobulinemia, ANA/ASMA +
Chronic Hepatitis B Virus	HBsAg+, HBeAg may be +
Hemochromatosis	Family history+, Fe/TIBC and ferritin elevated
Wilson’s disease	Family history+, young age, low ceruloplasmin
Alpha-1-antitrypsin (AAT) deficiency	Family history+, young age, low serum AAT