Complement component 3

Complement component 3
PDB rendering based on 1c3d.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1c3d​, 1ghq​, 1w2s​, 2a73​, 2a74​, 2b39​, 2gox​, 2hr0​, 2i07​, 2ice​, 2icf​
Identifiers
Symbols	C3 ; ASP; CPAMD1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68031
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

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Definitions
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

In immunology, soluble C3-convertase, also known as C4b2a, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the classical complement system as well as the Mannan-binding lectin pathway. In the Alternative complement pathway, C3 is instead cleaved by iC3Bb, another form of C3-convertase.

See also

• Complement system

External links

• Sahu A, Lambris J (2001). "Structure and biology of complement protein C3, a connecting link between innate and acquired immunity". Immunol Rev. 180: 35–48. doi:10.1034/j.1600-065X.2001.1800103.x. PMID 11414361.
• Fredslund F, Jenner L, Husted L, Nyborg J, Andersen G, Sottrup-Jensen L (2006). "The structure of bovine complement component 3 reveals the basis for thioester function". J Mol Biol. 361 (1): 115–27. doi:10.1016/j.jmb.2006.06.009. PMID 16831446.CS1 maint: Multiple names: authors list (link)
• PDB: 2B39​, PDB: 2A73​
• domain structure; protein database
• Complement+C3 at the US National Library of Medicine Medical Subject Headings (MeSH)