Mesial temporal sclerosis

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Evidence Based Medicine
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Clinical Trials
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Guidelines / Policies / Govt
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Commentary
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Definitions
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mesial temporal sclerosis is a specific pattern of hippocampal neuron cell loss^[1] ^[2]. There are 3 specific patterns of cell loss; Cell loss might involve sectors CA1 and CA4, CA4 alone, or CA1 to CA4 ^[3]. Associated hippocampal atrophy and gliosis is common^[4]. MRI scan commonly displays increased T2 signal and hippocampal atrophy ^[5] Mesial temporal sclerosis might occur with other temporal lobe abnormalities (dual pathology) ^[6]. Mesial temporal sclerosis is the most common pathological abnormality in temporal lobe epilepsy^[7] ^[8].