Carcinoid syndrome physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
A patient may present and verbally identify symptoms such as flushing and diarrhea. During examination, evidence of T.I.P.S. - tricuspid insufficency pulmonic stenosis may appear. In many cases, increased levels of 5-HIAA may be found in urine specimens.
Physical Examination
Clinical findings include:[1]
- Flushing of the skin
- Diarrhea and abdominal cramps
- Right sided heart disease
- Bronchoconstriction
- Abdominal pain due to desmoplastic reaction of the mesentery
- In most patients, increased urinary excretion of 5-HIAA (5-hydroxyindoleacetic acid), a degradation product of serotonin
- Serotonin causes fibrosis of the tricuspid valve and pulmonary valve
- "TIPS" - Tricuspid Insufficiency, Pulmonic Stenosis (fibrosis of tricuspid and pulmonary valves)
References
- ↑ E.Goljan, Pathology, 2nd ed Mosby Elsevier, Rapid Review series.