Acute myeloblastic leukemia with maturation
| Acute myeloblastic leukemia with maturation | |
 | |
|---|---|
| Myeloblast | |
| ICD-O: | Template:ICDO |
| MeSH | D015470 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
M2 is a subtype of AML (Acute Myeloid Leukemia).
It is also known as "Acute Myeloblastic Leukemia with Maturation".[1]
Cause
This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).[2] On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes.
The two different proteins that are fused together are:
References
- ↑ "Acute Myeloid Leukemia - Signs and Symptoms".
- ↑ Taj AS, Ross FM, Vickers M; et al. (1995). "t(8;21) myelodysplasia, an early presentation of M2 AML". Br. J. Haematol. 89 (4): 890–2. PMID 7772527.
External links