Antimicrosomal antibody
| Antimicrosomal antibody |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and Related Keywords: Thyroid antimicrosomal antibody; Antimicrosomal antibody; Microsomal antibody; Thyroid peroxidase antibody; TPOAb
Overview
Antithyroid microsomal antibody is a test to measure antithyroid microsomal antibodies in the blood. Microsomes are found inside thyroid cells. The body produces antibodies to microsomes when there has been damage to thyroid cells. [1] [2] [3]
Differential diagnoses
A negative test is normal. A positive test may be due to:
- Autoimmune hemolytic anemia
- Granulomatous thyroiditis
- Hashimoto's thyroiditis
- Nontoxic nodular goiter
- Rheumatoid arthritis
- Sjogren syndrome
- Systemic lupus erythematosus
- Thyroid cancer
High levels of these antibodies have also been linked to an increased risk of:
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
References
- ↑ Mecacci F, Parretti E, Cioni R, et al. Thyroid autoimmunity and its association with non-organ-specific antibodies and subclinical alterations of thyroid function in women with a history of pregnancy loss or preeclampsia. J Reprod Immunol. 2000 Feb;46(1):39-50.
- ↑ Vaquero E, Lazzarin N, De Carolis C, Valensise H, Moretti C, Ramanini C. Mild thyroid abnormalities and recurrent spontaneous abortion: diagnostic and therapeutical approach. Am J Reprod Immunol. 2000 Apr;43(4):204-8.
- ↑ Ladenson P, Kim M. Thyroid. In: Goldman L and Ausiello D, eds. Goldman: Cecil Medicine. 23rd ed. Philadelphia, Pa:Saunders; 2007:chap 244.