Calcitonin gene-related peptide

calcitonin-related polypeptide, beta
Identifiers
Symbol	CALCB
Alt. symbols	CALC2
Entrez	797
HUGO	1438
OMIM	114160
RefSeq	NM_000728
UniProt	P10092
Other data
Locus	Chr. 11 p14.2-p12

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Calcitonin gene related peptide (CGRP) is derived, with calcitonin, from the CT/CGRP gene located on chromosome 11. CGRP is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known.

CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide is the brain. This effect was found to be antagonised by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migrane headaches.

External Links

• Calcitonin+Gene-Related+Peptide at the US National Library of Medicine Medical Subject Headings (MeSH)