Deoxycholic acid

Overview

WikiDoc Resources for Deoxycholic acid
Articles
Most recent articles on Deoxycholic acid Most cited articles on Deoxycholic acid Review articles on Deoxycholic acid Articles on Deoxycholic acid in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Deoxycholic acid Images of Deoxycholic acid Photos of Deoxycholic acid Podcasts & MP3s on Deoxycholic acid Videos on Deoxycholic acid
Evidence Based Medicine
Cochrane Collaboration on Deoxycholic acid Bandolier on Deoxycholic acid TRIP on Deoxycholic acid
Clinical Trials
Ongoing Trials on Deoxycholic acid at Clinical Trials.gov Trial results on Deoxycholic acid Clinical Trials on Deoxycholic acid at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Deoxycholic acid NICE Guidance on Deoxycholic acid NHS PRODIGY Guidance FDA on Deoxycholic acid CDC on Deoxycholic acid
Books
Books on Deoxycholic acid
News
Deoxycholic acid in the news Be alerted to news on Deoxycholic acid News trends on Deoxycholic acid
Commentary
Blogs on Deoxycholic acid
Definitions
Definitions of Deoxycholic acid
Patient Resources / Community
Patient resources on Deoxycholic acid Discussion groups on Deoxycholic acid Patient Handouts on Deoxycholic acid Directions to Hospitals Treating Deoxycholic acid Risk calculators and risk factors for Deoxycholic acid
Healthcare Provider Resources
Symptoms of Deoxycholic acid Causes & Risk Factors for Deoxycholic acid Diagnostic studies for Deoxycholic acid Treatment of Deoxycholic acid
Continuing Medical Education (CME)
CME Programs on Deoxycholic acid
International
Deoxycholic acid en Espanol Deoxycholic acid en Francais
Business
Deoxycholic acid in the Marketplace Patents on Deoxycholic acid
Experimental / Informatics
List of terms related to Deoxycholic acid

Deoxycholic acid, also known as deoxycholate, cholanoic acid, and 3α,12α-dihydroxy-5β-cholanate, is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The two primary bile acids secreted by the liver are cholic acid and chenodeoxycholic acid. Bacteria metabolize chenodeoxycholic acid into the secondary bile acid lithocholic acid, and they metabolize cholic acid into deoxycholic acid. There are additional secondary bile acids, such as ursodeoxycholic acid. Deoxycholic acid is soluble in alcohol and acetic acid. When pure, it comes in a white to off-white crystalline powder form.

Applications

In the human body deoxycholic acid is used in the emulsification of fats for the absorption in the intestine. Outside the body it is used in experimental basis of cholagogues and is also use to prevent and dissolve gallstones.

Sodium deoxycholate, the sodium salt of deoxycholic acid, is frequently used in mesotherapy injections, mixed with phosphatidylcholine.

In research deoxycholic acid is used as a mild detergent for the isolation of membrane associated proteins.

Deoxycholates and bile acid derivatives in general are actively being studied as structures for incorporation in nanotechnology. They also have found application in microlithography as photoresist components.

The critical micelle concentration for deoxycholic acid is approximately 0.2%.

Sodium deoxycholate, the sodium salt of deoxychlic acid, is often used as a biological detergent to lyse cells and solubilise cellular and membrane components.

See also

• Ursodiol (ursodeoxycholic acid)
• Bile acids