Etonogestrel

Etonogestrel

Clinical data
Routes of administration	Subdermal as slow-release implant
ATC code	G03AC08 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic (P450 3A4)
Elimination half-life	25 hours
Excretion	Urinary (majority) and fecal
Identifiers
IUPAC name 13-ethyl-17-ethynyl- 17-hydroxy-11-methylidene- 2,6,7,8,9,10,12,13,14,15,16,17- dodecahydro- 1H-cyclopenta[a] phenanthren-3-one
CAS Number	54048-10-1
PubChem CID	40976
DrugBank	APRD00766
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H28O2
Molar mass	324.457 g/mol

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Etonogestrel is a molecule used in hormonal contraceptives, most notably the subdermal implant Implanon.

Etonogestrel, the specific progestin used in NuvaRing, is the active metabolite of the inactive prodrug desogestrel, one of two third-generation progestins found in some epidemiological studies of combined oral contraceptive pills to be associated with a higher risk of venous thrombosis than combined oral contraceptive pills containing certain second-generation progestins. Because hormones are released continuously from NuvaRing, peak and total estrogen and progestin doses are significantly lower than with combined oral contraceptives, although it is not known whether this lowers the risk of blood clots.

See also

• Progestin
• Progestagen