Fundic glands

Overview

The fundus glands (or fundic glands, or gastric glands) are found in the body and fundus of the stomach.

They are simple tubes, two or more of which open into a single duct.

Fundic gland polyposis is a medical syndrome where the fundus of the stomach develops many polyps.

Location	Name	Description	Secretion	Staining
Isthmus	mucous cells	In gastric pits.	mucus gel layer	Clear
Neck	parietal (oxyntic) cells	Between the chief cells and the basement membrane, larger oval cells, which stain deeply with eosin, are found; these cells are studded throughout the tube at intervals, giving it a beaded or varicose appearance. These are known as the parietal cells or oxyntic cells, and they are connected with the lumen by fine channels which run into their substance.	gastric acid and intrinsic factor	Acidophilic
Base	chief (zymogenic) cells	At the point where they open into the duct, which is termed the neck, the epithelium alters, and consists of short columnar or polyhedral, granular cells, which almost fill the tube, so that the lumen becomes suddenly constricted and is continued down as a very fine channel. They are known as the chief cells or central cells of the glands.	pepsinogen, rennin	Basophilic
Base	enteroendocrine (APUD) cells	-	hormones	-

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