HLA-A74
major histocompatibility complex (human), class I, A74
| ||
| Alleles | A*7401 A*7403 | |
| Structure (See HLA-A) | ||
| Identifiers | 7401 7403
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*7401 | |
| EBI-HLA | A*7403 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A74 (A74) is an HLA-A serotype. The serotype identifies the HLA-A*7401 gene product. A74 is a split antigen type of the A19 broad antigen type. A74 is rare.
Serotype
| A*74 | A74 | A19 | Sample |
| allele | % | % | size (N) |
| 7401 | 40 | 11 | 119 |
| 7401 | 17 | 29 |
Disease associations
A significant association has been found between A74 and nasal polyposis.[2]
A*74 allele Frequencies
| freq | ||
| ref. | Population | (%) |
| [3] | Kenya | 9.7 |
| [3] | Cameroon Beti | 8.3 |
| [3] | Guinea Bissau | 7.7 |
| [3] | Burkina Faso Mossi | 6.6 |
| [3] | Uganda Kampala | 5.2 |
| [3] | Cameroon Yaounde | 5.0 |
| [3] | Cameroon Bamileke | 4.5 |
| [3] | Cameroon Sawa | 3.8 |
| [3] | Mali Bandiagara | 3.6 |
| [3] | Iran Baloch | 2.8 |
| [3] | Zimbabwe Harare Shona | 2.7 |
| [3] | Senegal Niokholo Mandenka | 2.2 |
| [3] | Burkina Faso Rimaibe | 2.1 |
| [3] | Kenya Nandi | 1.7 |
| [3] | Morocco Nador Metalsa | 1.4 |
| [3] | Thailand Northeast | 1.2 |
| [3] | Thailand | 1.1 |
| [3] | Jordon Amman | 0.7 |
| [3] | Jordon Amman | 0.5 |
| [3] | China South | 0.5 |
| freq | ||
| ref. | Population | (%) |
| [3] | Kenya Luo | 7.3 |
| [3] | Iran Baloch | 0.6 |
| [3] | Kenya | 0.3 |
| [3] | Uganda Kampala | 0.3 |
References
- ↑ derived from IMGT/HLA
- ↑ Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D (2000). "HLA patterns in patients with nasal polyposis". European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 257 (3): 137–9. PMID 10839486.
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in
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