Juvenile myelomonocytic leukemia radiation therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Radiation/Radiotherapy
Radiation to the spleen does not generally result in a decrease in spleen size or reduction of platelet transfusion requirement.
Conditioning regimen
The COG JMML Study involves 8 rounds of total-body irradiation (TBI) and doses of cyclophosphamide to prepare the JMML child’s body for bone marrow transplant. Use of TBI is controversial, though, because of the possibility of late side-effects such as slower growth, sterility, learning disabilities, and secondary cancers, and the fact that radiation can have devastating effects on very young children. It is used in this study, however, due to the concern that chemotherapy alone might not be enough to kill dormant JMML cells. The EWOG-MDS JMML Study includes busulfan in place of TBI due to its own research findings that appeared to show that busulfan was more effective against leukemia in JMML than TBI. The EWOG-MDS study also involves cyclophosphamide and melphalan in its conditioning regimen.