Lactoferrin

Lactoferrin
Identifiers
Symbol	LF
Entrez	4057
HUGO	6720
OMIM	150210
RefSeq	NM_002343
UniProt	P02788
Other data
Locus	Chr. 3 q21-23

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Lactoferrin (LF), a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide), is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva. Lactoferrin is also present in secondary granules of PMN and also is secreted by some acinar cells. Human colostrum has the highest concentration, followed by human milk, then cow milk.

Structure

Lactoferrin belongs to the transferrin family proteins (TF, melanotransferrin, ovotransferin, etc.). Its molecular mass is 80,000 u (80 kDa).

Function

Lactoferrin antimicrobial activity is due partly to its high affinity for Fe (ferric state). LF proteolysis produces lactoferricin, kaliocin-1 small peptides with antimicrobial activity.

Lactoferrin receptors have been found on brush-border cells, PMN, monocytes, Mφ and activated lymphocytes.

Genetics

Genetically modified (transgenic) rice LL601 (Liberty Link 601) produces this protein.

External links

• Thompson.net Supported information about lactoferrin.
• FDA Lactoferrin Considered Safe to Fight E. Coli.
• lactoferrinresearch.org
• Agennix.com A biopharmaceutical company focused on developing protein-based drugs for cancer and diabetic ulcers.
• Pharming.com A biopharmaceutical company producing lactoferrin.

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