Leukocyte alkaline phosphatase

Leukocyte alkaline phosphatase

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

• Alkaline phosphatase is an enyzme present throughout the body
• Alkaline phosphatase functions optimally at pH 8.6
• Leukocyte alkaline phosphatase is a test that tests the level of enzyme within the white blood cells
• Sometimes referred to as LAP

Differential Diagnosis

In alphabetical order.

Decreased

• Anemia
• Chronic Myelogenous Leukemia
• Hemolysis
• Iron deficiency anemia
• Sideroachrestic anemia (SA)

Increased

• Acute leukemia
• Aplastic Anemia
• Malignant lymphomas
• Megaloblastic anemia
• Multiple Myeloma
• Osteomyelofibrosis
• Polycythemia Vera
• Solid tumors
• Tissue necrosis

References

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