Central pontine myelinolysis

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Central pontine myelinolysis
Pons labeled at bottom left
ICD-10	G37.2
DiseasesDB	2198
MedlinePlus	000775
MeSH	D017590

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: CPM; osmotic demyelination syndrome; osmotic myelinolysis

Overview

Central pontine myelinolysis is a neurologic disease caused by severe damage of the myelin sheath of nerve cells in the brainstem, more precisely in the area termed the pons.

Causes

The most common cause is the rapid correction of low blood sodium levels (hyponatremia).

Risk Factors

It has been postulated that the real cause might be the lack of a substance that is essential for brain activity and is lacking due to malnutrition.

The fact that this condition is most frequently observed in patients with general ill health (alcoholism, cachexia etc.) is in accordance with this assumption.

Diagnosis

Symptoms

Frequently observed symptoms in this disorder are sudden para or quadraparesis, dysphagia, dysarthria, double vision and loss of consciousness. The patient may experience locked-in syndrome where cognitive function is intact, but all muscles are paralyzed with the exception of eye blinking.

MRI

Imaging by MRI demonstrates an area of high signal return on T2 weighted images.

Treatment

To avoid myelinolysis, the correction of hyponatremia should not exceed 1 mEq/L per hour.