PARK7

Parkinson disease (autosomal recessive, early onset) 7
File:PBB Protein PARK7 image.jpg PDB rendering based on 1j42.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1j42​, 1p5f​, 1pdv​, 1pdw​, 1pe0​, 1ps4​, 1q2u​, 1soa​, 1ucf​, 2or3​
Identifiers
Symbols	PARK7 ; DJ-1; DJ1; FLJ27376
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38295
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PARK7 200007 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Parkinson disease (autosomal recessive, early onset) 7, also known as PARK7, is a human gene. It is also known as DJ-1.

See also

• Parkinson's disease

Further reading

• Cookson MR (2003). "Pathways to Parkinsonism". Neuron. 37 (1): 7–10. PMID 12526767.
• Bonifati V, Oostra BA, Heutink P (2004). "Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease". J. Mol. Med. 82 (3): 163–74. doi:10.1007/s00109-003-0512-1. PMID 14712351.CS1 maint: Multiple names: authors list (link)
• Le W, Appel SH (2004). "Mutant genes responsible for Parkinson's disease". Current opinion in pharmacology. 4 (1): 79–84. doi:10.1016/j.coph.2003.09.005. PMID 15018843.
• Abou-Sleiman PM, Healy DG, Wood NW (2005). "Causes of Parkinson's disease: genetics of DJ-1". Cell Tissue Res. 318 (1): 185–8. doi:10.1007/s00441-004-0922-6. PMID 15503154.CS1 maint: Multiple names: authors list (link)
• Pankratz N, Foroud T (2005). "Genetics of Parkinson disease". NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. 1 (2): 235–42. PMID 15717024.
• Heutink P (2006). "PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease". J. Neural Transm. Suppl. (70): 215–9. PMID 17017532.
• Lev N, Roncevic D, Roncevich D; et al. (2007). "Role of DJ-1 in Parkinson's disease". J. Mol. Neurosci. 29 (3): 215–25. PMID 17085780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagakubo D, Taira T, Kitaura H; et al. (1997). "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras". Biochem. Biophys. Res. Commun. 231 (2): 509–13. doi:10.1006/bbrc.1997.6132. PMID 9070310.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taira T, Takahashi K, Kitagawa R; et al. (2001). "Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter". Gene. 263 (1–2): 285–92. PMID 11223268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Duijn CM, Dekker MC, Bonifati V; et al. (2001). "Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36". Am. J. Hum. Genet. 69 (3): 629–34. PMID 11462174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi K, Taira T, Niki T; et al. (2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". J. Biol. Chem. 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonifati V, Rizzu P, van Baren MJ; et al. (2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism". Science. 299 (5604): 256–9. doi:10.1126/science.1077209. PMID 12446870.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonifati V, Dekker MC, Vanacore N; et al. (2003). "Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7". Neurol. Sci. 23 Suppl 2: S59–60. doi:10.1007/s100720200069. PMID 12548343.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Niki T, Takahashi-Niki K, Taira T; et al. (2004). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Mol. Cancer Res. 1 (4): 247–61. PMID 12612053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tao X, Tong L (2003). "Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease". J. Biol. Chem. 278 (33): 31372–9. doi:10.1074/jbc.M304221200. PMID 12761214.
• Honbou K, Suzuki NN, Horiuchi M; et al. (2003). "The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease". J. Biol. Chem. 278 (33): 31380–4. doi:10.1074/jbc.M305878200. PMID 12796482.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dekker M, Bonifati V, van Swieten J; et al. (2004). "Clinical features and neuroimaging of PARK7-linked parkinsonism". Mov. Disord. 18 (7): 751–7. doi:10.1002/mds.10422. PMID 12815653.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miller DW, Ahmad R, Hague S; et al. (2003). "L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system". J. Biol. Chem. 278 (38): 36588–95. doi:10.1074/jbc.M304272200. PMID 12851414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

Template:WikiDoc Sources