SOSTDC1
| Sclerostin domain containing 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | SOSTDC1 ; CDA019; DKFZp564D206; ECTODIN; USAG1 | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 9154 | ||||||||
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| RNA expression pattern | |||||||||
| File:PBB GE SOSTDC1 213456 at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
Sclerostin domain containing 1, also known as SOSTDC1, is a human gene.[1]
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[1]
References
Further reading
- Yanagita M (2006). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine Growth Factor Rev. 16 (3): 309–17. doi:10.1016/j.cytogfr.2005.02.007. PMID 15951218.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Laurikkala J, Kassai Y, Pakkasjärvi L; et al. (2004). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Dev. Biol. 264 (1): 91–105. PMID 14623234.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Yanagita M, Oka M, Watabe T; et al. (2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochem. Biophys. Res. Commun. 316 (2): 490–500. doi:10.1016/j.bbrc.2004.02.075. PMID 15020244.
- Goto M, Eddy EM (2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". J. Biol. Chem. 279 (40): 42128–38. doi:10.1074/jbc.M403190200. PMID 15280373.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.