Polycystic kidney disease natural history
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Differentiating Polycystic kidney disease from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]
Overview
Polycystic kidney disease is a multiorgan and progressive disorder characterized by formation of cysts in kidney and other organs like pancreas, liver and spleen.
Natural History
- Symptoms of polycystic kidney disease begin in the third or fourth decade of life. However, the renal cysts can be detected as early as childhood or in utero.
- The cysts gradually grow in size replacing most of the renal tissue with cysts, compromising its normal function.
- Creatinine begins to built up and eventually the patient goes into end stage renal disease.
Complications
- Anemia
- Rupture of cysts
- Infection of liver cysts
- Chronic renal failure
- Hypertension
- Nephrolithiasis
- Liver failure
- Urinary tract infection
Prognosis
- The disease gets worse slowly. Eventually it leads to end-stage chronic renal failure.
- It is also associated with liver disease, including infection of liver cysts.
- Medical treatment may relieve symptoms for many years.
- People with PKD who do not have other diseases may be good candidates for a kidney transplant.