Sulbactam

Sulbactam

File:Sulbactam.svg
Clinical data
Routes of administration	Injection
ATC code	J01CG01 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	1
Excretion	Kidneys?
Identifiers
IUPAC name (2R,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1- azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS Number	68373-14-8
PubChem CID	130313
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C8H11NO5S
Molar mass	233.243 g/mol

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Sulbactam is a molecule which is given in combination with beta-lactam antibiotics to inhibit beta-lactamase, an enzyme produced by bacteria that destroys the antibiotics. Sulbactam is an irreversible inhibitor of beta-lactamase; it binds the enzyme and does not allow it to interact with the antibiotic. Sulbactam is able to inhibit the most common forms of beta-lactamase but is not able to interact with the ampC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene. In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.

References

• Singh GS. Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam. Mini Rev Med Chem. 2004 Jan;4(1):93-109. Review. PMID 14754446