Thiostrepton

WikiDoc Resources for Thiostrepton
Articles
Most recent articles on Thiostrepton Most cited articles on Thiostrepton Review articles on Thiostrepton Articles on Thiostrepton in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Thiostrepton Images of Thiostrepton Photos of Thiostrepton Podcasts & MP3s on Thiostrepton Videos on Thiostrepton
Evidence Based Medicine
Cochrane Collaboration on Thiostrepton Bandolier on Thiostrepton TRIP on Thiostrepton
Clinical Trials
Ongoing Trials on Thiostrepton at Clinical Trials.gov Trial results on Thiostrepton Clinical Trials on Thiostrepton at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Thiostrepton NICE Guidance on Thiostrepton NHS PRODIGY Guidance FDA on Thiostrepton CDC on Thiostrepton
Books
Books on Thiostrepton
News
Thiostrepton in the news Be alerted to news on Thiostrepton News trends on Thiostrepton
Commentary
Blogs on Thiostrepton
Definitions
Definitions of Thiostrepton
Patient Resources / Community
Patient resources on Thiostrepton Discussion groups on Thiostrepton Patient Handouts on Thiostrepton Directions to Hospitals Treating Thiostrepton Risk calculators and risk factors for Thiostrepton
Healthcare Provider Resources
Symptoms of Thiostrepton Causes & Risk Factors for Thiostrepton Diagnostic studies for Thiostrepton Treatment of Thiostrepton
Continuing Medical Education (CME)
CME Programs on Thiostrepton
International
Thiostrepton en Espanol Thiostrepton en Francais
Business
Thiostrepton in the Marketplace Patents on Thiostrepton
Experimental / Informatics
List of terms related to Thiostrepton

Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes, such as Streptomyces azureus, Streptomyces laurentii.

Properties

• Synonyms: Alaninamide, Bryamycin , Thiactin
• CAS number: 1393-48-2
• Merck index: 14: 9364
• Molecular weight: 1664.89
• Molecular Formula: C72H85N19O18S5
• Melting point: decomposes at 246-256oC
• Solubility information: Soluble in chloroform, dichloromethane, dioxane, pyridine, glacial acetic acid, DMF. Practically insoluble in water, the lower alcohols, nonpolar organic solvents, diluted aqeous acids or bases. May be dissolved by methanolic acid or base, but with decomposition. Working solution of 1% in DMSO is unstable and should be freshly prepared and protected from light.
• Appearance: White to off-white powder

History

Thiostrepton was discovered by DONOVICK R, PAGANO JF, STOUT HA, WEINSTEIN MJ. in 1955 (Antibiot Annu. 1955-1956;3:554-9), who desribed its antibacterial properties.

Dorothy Crowfoot Hodgkin solved the structure of Thiostrepton in 1970.

Applications

Thiostrepton has been used in veterinary medicine in mastitis caused by gram-negative organisms and in dermatologic disorders. It is mostly used in complex ointments containing Neomycin, Nystatin, Thiostrepton and topical steroides. It is also active against gram-positive bacteria.

Recently, Thiostrepton has been reported to exhibit antimalarial and anticancer activities

Thiostrepton is used in molecular biology as a reagent for both positive and negative selection of genes involved in nucleotide metabolism.

References

Physicochemical data copied with permission from Thiostrepton product page from Fermentek