Topotecan (injection)

Topotecan (injection)

Clinical data
Pregnancy category	D (Au, U.S.)
Routes of administration	Intravenous infusion, oral
ATC code	L01XX17 (WHO)
Legal status
Legal status	℞-only (U.S.), POM (UK)
Pharmacokinetic data
Bioavailability	NA
Protein binding	35%
Metabolism	Hepatic
Elimination half-life	2-3 hours
Excretion	Renal
Identifiers
IUPAC name (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b] quinoline-3,14(4H,12H)-dione monohydrochloride
CAS Number	119413-54-6
PubChem CID	6419854
DrugBank	APRD00687
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C23H23N3O5 •HCl
Molar mass	457.9 g/mol

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Overview

Topotecan hydrochloride (Hycamtin) is a chemotherapy agent that is a topoisomerase 1 inhibitor. It is used to treat ovarian cancer and lung cancer, as well as other cancer types.

After GlaxoSmithKline received final FDA approval for Hycamtin Capsules on October 15, 2007, Topotecan is the first topoisomerase inhibitor for oral use.

Administration

IV, oral.

Side effects

• Diarrhea
• Low blood counts
• Susceptibility to infection

See also

NCI Drug Dictionary Definition of Topotecan
NCI Drug Information for Patients