Toremifene

Toremifene

Clinical data
ATC code	L02BA02 (WHO)
Pharmacokinetic data
Protein binding	more than 99.5%
Elimination half-life	5 days
Identifiers
IUPAC name 2-[4-(4-chloro-1, 2-diphenyl-but-1-enyl)phenoxy]- N,N-dimethyl-ethanamine
CAS Number	89778-26-7
PubChem CID	3005573
DrugBank	APRD00391
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C26H28ClNO
Molar mass	405.959 g/mol

WikiDoc Resources for Toremifene
Articles
Most recent articles on Toremifene Most cited articles on Toremifene Review articles on Toremifene Articles on Toremifene in N Eng J Med, Lancet, BMJ
Media
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Evidence Based Medicine
Cochrane Collaboration on Toremifene Bandolier on Toremifene TRIP on Toremifene
Clinical Trials
Ongoing Trials on Toremifene at Clinical Trials.gov Trial results on Toremifene Clinical Trials on Toremifene at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Toremifene NICE Guidance on Toremifene NHS PRODIGY Guidance FDA on Toremifene CDC on Toremifene
Books
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News
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Commentary
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Definitions
Definitions of Toremifene
Patient Resources / Community
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Healthcare Provider Resources
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Continuing Medical Education (CME)
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International
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Business
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Experimental / Informatics
List of terms related to Toremifene

Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

GTx Inc. is currently conducting two different phase 3 clinical trials; First, a pivotal Phase clinical trial for the treatment of serious side effects of androgen deprivation therapy (especially vertebral/spine fractures and hot flashes, lipid profile, and gynecomastia) for advanced prostate cancer, and second, a pivotal Phase III clinical trial for the prevention of prostate cancer in high risk men with high grade prostatic intraepithelial neoplasia, or PIN. Results of these trials are expected by first quarter of 2008