Chronic cholecystitis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pathophysiology

Acute cholecystitis

Cholecystitis is caused by obstruction of bile duct due to impaction of gall stone^[1] . Gall stone impaction leads to damage to mucosal surface of gall bladder and bile stasis. Factors which induce cholecystits are

Lithogenic bile
Duct obstruction

Acute inflammation is not always necessary for the development of acute cholecystitis.

Chronic Cholecystitis

There are few studies suggesting role of pancreatic biliary reflux as a co factor for the development of chronic cholecystitis. Occult pancreatic biliary reflux can be diagnosed by measuring levels of biliary amylase levels. ^[2]

Acute Acalculous Cholecystitis

Pathology

Chornic cholecystitis

References

↑ Roslyn JJ, DenBesten L, Thompson JE, Silverman BF (1980). "Roles of lithogenic bile and cystic duct occlusion in the pathogenesis of acute cholecystitis". American Journal of Surgery. 140 (1): 126–30. PMID 7396076. Retrieved 2012-08-20. Unknown parameter |month= ignored (help)
↑ Amr AR, Hamdy HM, Nasr MM, Hedaya MS, Hassan AM (2012). "Effect of pancreatic biliary reflux as a cofactor in cholecystitis". Journal of the Egyptian Society of Parasitology. 42 (1): 121–8. PMID 22662601. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

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[pmid7396076-1] Roslyn JJ, DenBesten L, Thompson JE, Silverman BF (1980). "Roles of lithogenic bile and cystic duct occlusion in the pathogenesis of acute cholecystitis". American Journal of Surgery. 140 (1): 126–30. PMID 7396076. Retrieved 2012-08-20. Unknown parameter |month= ignored (help)

[pmid22662601-2] Amr AR, Hamdy HM, Nasr MM, Hedaya MS, Hassan AM (2012). "Effect of pancreatic biliary reflux as a cofactor in cholecystitis". Journal of the Egyptian Society of Parasitology. 42 (1): 121–8. PMID 22662601. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

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