Amyotrophic lateral sclerosis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
- ALS is one of the most common neuromuscular diseases worldwide, and people of all races and ethnic backgrounds are affected.
- Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women.
- Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (i.e., husband and wife) cases in the south of France[1][2][3][4][5], these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.
References
- ↑ Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F (1998). "Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy". Ital J Neurol Sci. Apr;19 (2): 97–100. PMID: 10935845.
- ↑ Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F (1997). "Conjugal amyotrophic lateral sclerosis: toxic clustering or change?". Ital J Neurol Sci. Apr;18 (2): 109–12. PMID: 9239532.
- ↑ Camu W, Cadilhac J, Billiard M. (1994). "Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France". Neurology. Mar;44 (3 Pt 1): 547–8. PMID: 8145930.
- ↑ Cornblath DR, Kurland LT, Boylan KB, Morrison L, Radhakrishnan K, Montgomery M. (1993). "Conjugal amyotrophic lateral sclerosis: report of a young married couple". Neurology. Nov;43 (11): 2378–80. PMID: 8232960.
- ↑ Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, Pouget J, Camu W (2003). "A clustering of conjugal amyotrophic lateral sclerosis in southeastern France". Neurol. Apr;60 (4): 553–7. PMID: 12707069.