Amyotrophic lateral sclerosis risk factors

Revision as of 14:30, 24 August 2012 by Aarti Narayan (talk | contribs)
Jump to navigation Jump to search

Amyotrophic lateral sclerosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Amyotrophic lateral sclerosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Amyotrophic lateral sclerosis risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Amyotrophic lateral sclerosis risk factors

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Amyotrophic lateral sclerosis risk factors

CDC on Amyotrophic lateral sclerosis risk factors

Amyotrophic lateral sclerosis risk factors in the news

Blogs on Amyotrophic lateral sclerosis risk factors

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Amyotrophic lateral sclerosis risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Risk Factors

  • Defective mutation in chromosome 21, inherited in an autosomal dominant pattern.
  • The children of those diagnosed with familial ALS have a higher risk factor for developing the disease; however, those who have close family members diagnosed with sporadic ALS have no greater a risk factor than the general population
  • Prolonged exposure to a dietary neurotoxin is one suspected risk factor in Guam; the neurotoxin is a compound found in the seed of the cycad Cycas circinalis,[1] a tropical plant found in Guam, which was used in the human food supply during the 1950s and early 1960s.
  • According to the ALS Association, military veterans are at an increased risk of contracting ALS. In its report ALS in the Military,[2] the group pointed to an almost 60% greater chance of the disease in military veterans than the general population. For Gulf War veterans, the chance is seen as twice that of the general population in a joint study by the Veterans Affairs Administration and the DOD.

References

  1. Bains J, et al. (2002). "Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex".J. Neurochem. 82(3):516-28. PMID: 12153476.
  2. "ALS in the Military" (PDF). The ALS Association. 2007-05-17. Retrieved 2008-05-01.

Template:WH Template:WS