Polycystic ovary syndrome natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Complications
Women with PCOS are at risk for the following complications:
- Endometrial hyperplasia and endometrial cancer (cancer of the uterine lining) are possible, due to overaccumulation of uterine lining, and also lack of progesterone resulting in prolonged stimulation of uterine cells by estrogen
- Insulin resistance/Type II diabetes
- High blood pressure
- Dyslipidemia (disorders of lipid metabolism — cholesterol and triglycerides)
- Cardiovascular disease
- Strokes
- Weight gain
- Miscarriage
- Excessive amounts of androgens
- Lack of regular ovulation
- Infertility (early treatment of polycystic ovary disease can help prevent infertility or increase the chance of having a healthy pregnancy)
- Possible increased risk of breast cancer