Eosinophilia

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Eosinophilia
DiseasesDB 4328

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]

Overview

  • Eosinphilia refers to a group of idiopathic, neoplastic, infectious and allergic illnesses
  • Eosinphilia is associated with abnormally high number of eosinphil granulocytes in the serum and/or tissue
  • Reference range: 0-450 ul

Differential Diagnosis of Causes of Eosinophilia

By Organ System

Cardiovascular Endomyocardial fibrosis, Cholesterol embolism, Loeffler endocarditis , Eosinophilic myocarditis
Chemical / poisoning No underlying causes
Dermatologic Erythema multiforme, Atopic dermatitis, Dermatitis herpetiformis, Eosinophilic fasciitis, Eosinophilic pustular folliculitis, Pemphigus vulgaris, Psoriasis, Systemic lupus erythematosus, Sarcoptes scabiei,

Eczema

Exfoliative dermatitis

Urticaria

Eosinophilic panniculitis

Shulman’s syndrome

Stevens - Johnson syndrome

Duhring disease Histiositosis with Cutaneous involvement

Drug Side Effect Sulphonamides, Allopurinol, Amitriptyline, Capreomycin, Caspofungin, Chlorpropamide, Clomipramine, Daptomycin, Desipramine, Dothiepin, Doxycycline, Enfuvirtide, Etravirine, Gold salts, Granulocyte-macrophage colony stimulating factor, Hydralazine, Imipramine, Interleukin 2, Micafungin, Minocycline, Nalidixic acid, Nitrofurantoin, Nortriptyline, Olanzapine, Oxytetracycline, Pentostatin, Procarbazine, Tobacco smoking, Tryptophan, Vancomycin,

Aldesleukin

Amikacin Sulfate

Capastat Sulfate

Capreomycin Sulfate

Cefotaxime Sodium

Cefoxitin Sodium

Ceftazidime

Cefuroxime

LyphocinMaolate

Ear Nose Throat No underlying causes
Endocrine Adrenal cortex insufficiency,

Addisons disease

Adrenocortical insufficiency

Environmental An allergic reaction to an environmental antigen
Gastroenterologic

Inflammatory Bowel Disease

Cirrhosis of liver

Chronic active hepatitis

Eosinophilic Gastroenteritis

Peritoneal dialysis

Genetic Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 2, Familial eosinophilia, Kostmann disease, Omenn syndrome, Wiskott-Aldrich syndrome,

TAR syndrome

kostmann syndrome

chromosome 21 partial deletion

Hematologic Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma,

Thrombocytopenia with absent radii

Familial reticuloendotheliosis with eosinophilia

Iatrogenic Radiotherapy
Infectious Disease Acanthocheilonemiasis, Alveolar hydatid disease, Ancylostoma caninum, Ancylostoma duodenale, Angiostrongyliasis, Anisakiasis, Ascariasis, Capillaria, Clonorchiasis, Coccidioidomycosis, Dicrocoelium dendriticum fluke, Dracunculiasis, Echinococcus granulosus, Fasciola hepatica, Gnathostomiasis, Heterophyiasis, Lepromatous leprosy, Loa loa filariasis, Lymphatic filariasis, Mansonelliasis, Metagonimiasis, Mycobacterium tuberculosis, Onchocerciasis, Opisthorchiasis, Paragonimiasis, Schistosoma haematobium, Schistosoma mansoni, Strongyloidiasis, Toxocariasis, Trichinella spiralis,

Pneumocystis jirovecii infection

Visceral larva migrans

Brucellosis

Cat-scratch fever

Chlamydial pneumonia of infancy

Infectious lymphocytosis

Infectious mononucleosis

Scarlet fever

Amebiasis

Malaria

Musculoskeletal / Ortho Polyarteritis nodosa, Polymyositis, Rheumatoid disease,

Dressler's syndrome

Eosinophilic fasciitis Idiopathic eosinophilic synovitis Progressive systemic sclerosis (scleroderma) SLE

Sjögren's syndrome

Sarcoidosis

Eosinophilia – Myalgia syndrome

Dermatomyositis

Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma,

Immunoblastic lymphadenopathy

Sarcomas and carcinomas of Ovary

Carcinoma of Pancreas

Carcinoma of Lung

Carcinoma of colon

Carcinoma of cervix

Acute eosinophilic leukemia Chronic eosinophilic leukemia

Brain Tumors

Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Simple pulmonary eosinophilia, Visceral larva migrans, Allergic bronchopulmonary aspergillosis, Extrinsic allergic alveolitis, Tropical pulmonary eosinophilia, Churg-Strauss syndrome, Bronchial asthma,

Allergic Rhinitis

Chronic eosinophilic pneumonia

Occupational lung diseases

Idiopathic eosinophilic chronic pneumopathy

Magrassi- Leonardi syndrome

Renal / Electrolyte Interstitial nephritis,

Interstitial nephritis

Eosinophilic cystitis

Hemodialysis

CRF not on renal replacement therapy

Diffuse proliferative glomerular nephritis

Thrombotic thrombocytopenic purpura

Renal cell carcinoma

Rheum / Immune / Allergy Eosinophilia-myalgia syndrome,

Hyper-IgE syndrome

IgA deficiency

Wiskott-Aldrich syndrome

Graft versus host immunologic reactions

Milk protein allergy

Omenn syndrome

Severe congenital Neutropenia

Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Angiolymphoid hyperplasia with eosinophilia, Eosinophilic cellulitis, Hypereosinophilic syndrome, Kimura disease

Familial eosinophilia Episodic angioedema with eosinophilia Aggressive systemic mastocytosis

In alphabetical order [1]

Related Chapters

References

  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:127-128 ISBN 1591032016


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