Squamous cell carcinoma of the skin other diagnostic studies
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Squamous cell carcinoma of the skin Microchapters |
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Differentiating Squamous cell carcinoma of the skin from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]
Overview
Other Diagnostic Studies
There are few other modalities used for diagnosis and follow up.
FTIR
- Fourier Transform Infrared Imaging(FTIR) is a modern analytic technique, which uses infrared rays to evaluate for the histology of the tissue & necessary for diagnosis at early stage.[4]
- It is a non invasive technique.
- It can be used in intra operative and surgical specimen analysis.
Immunohistochemistry
- There will be certain proteins/markers on the cell surface or in the matrix. Evaluation of them is useful in diagnosis and determining the prognosis.
- Expression of certain Cytokeratins(CK)by tumor cells is helpful in determining the metastatic ability.
- Few cells may express Involucrin on their surface which may help in diagnosis at times and differentiating from other kinds of tumors.[1]
- There is an extracellular protein called Laminin, which can be used for understanding tumor differentiation, invasion and prognostic indicator.[2]
References
- ↑ Suo Z, Holm R, Nesland JM (1993). "Squamous cell carcinomas. An immunohistochemical study of cytokeratins and involucrin in primary and metastatic tumours". Histopathology. 23 (1): 45–54. PMID 7690007. Unknown parameter
|month=ignored (help) - ↑ Koshy AV, Rao NN, Kamat SS, Kiswani K, Kapse SC, Shaikh NA (2012). "Expression of extracellular matrix-laminin in oral squamous cell carcinoma: an immunohistochemical study". J Contemp Dent Pract. 13 (2): 194–200. PMID 22665747.