Parkinson's disease historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Historical Perspective
Symptoms of Parkinson's disease have been known and treated since ancient times.[1]
However, it was not formally recognized and its symptoms were not documented until 1817 in An Essay on the Shaking Palsy[2] by the British physician James Parkinson. Parkinson's disease was then known as paralysis agitans, the term "Parkinson's disease" being coined later by Jean-Martin Charcot. The underlying biochemical changes in the brain were identified in the 1950s due largely to the work of Swedish scientist Arvid Carlsson, who later went on to win a Nobel Prize. L-dopa entered clinical practice in 1967,[3] and the first study reporting improvements in patients with Parkinson's disease resulting from treatment with L-dopa was published in 1968.[4]
References
- ↑ Manyam BV, Sánchez-Ramos JR (1999). "Traditional and complementary therapies in Parkinson's disease". Advances in neurology. 80: 565–74. PMID 10410773.
- ↑ Parkinson J (2002). "An essay on the shaking palsy. 1817" (Reproduced\). J Neuropsychiatry Clin Neurosci. 14 (2): 223–36, discussion 222. PMID 11983801.
- ↑ Hornykiewicz O (2002). "L-DOPA: from a biologically inactive amino acid to a successful therapeutic agent". Amino Acids. 23 (1–3): 65–70. doi:10.1007/s00726-001-0111-9. PMID 12373520.
- ↑ Cotzias, G. (1968). "L-Dopa for Parkinsonism". N Engl J Med. 278 (11): 630. PMID 5637779.