Scleroderma
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Scleroderma On the Web |
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American Roentgen Ray Society Images of Scleroderma |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
For patient information click here
Synonyms and keywords: Systemic sclerosis
Click here for The Heart in Scleroderma
Overview
Epidemiology
Pathophysiology
Etiology
Types of Scleroderma
Diagnosis
Diagnosis is by clinical suspicion, presence of autoantibodies (specifically anti-centromere and anti-scl70/anti-topoisomerase antibodies) and occasionally by biopsy. Of the antibodies, 90% have a detectable anti-nuclear antibody. Anti-centromere antibody is more common in the limited form (80-90%) than in the systemic form (10%), and anti-scl70 is more common in the diffuse form (30-40%) and in African-American patients (who are more susceptible to the systemic form).[1]
In 1980 the American College of Rheumatology agreed upon diagnostic criteria for scleroderma.[2]
Diffuse scleroderma can cause musculoskeletal, pulmonary, gastrointestinal, renal and other complications.[3]Patients with larger amounts of cutaneous involvement are more likely to have involvement of the internal tissues and organs.
Cardiovascular Symptoms
Skin Symptoms
Musculoskeletal System Related Symptoms
Respiratory System Symptoms
Gastrointestinal System Related Symptoms
Renal Symptoms
Therapy
Experimental treatments
Case Studies
References
- ↑ Jimenez SA, Derk CT (2004). "Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis". Ann. Intern. Med. 140 (1): 37–50. PMID 14706971.
- ↑ "Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee". Arthritis Rheum. 23 (5): 581–90. PMID 7378088. Text "year:1980 " ignored (help) Available online at "Criteria for the Classification of Systemic Sclerosis 1980". Text " accessdate:5 August 2007" ignored (help)
- ↑ Invalid
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External links
- Goldminer: Scleroderma
- DermnetNZ: Systemic sclerosis
- Juvenile Scleroderma Network
- Juvenile Systemic Sclerosis
- Scleroderma Foundation
- Scleroderma Society of Ontario
- International Scleroderma Network
- The Scleroderma Research Foundation
- UK Scleroderma Society
- Scleroderma Information from Johns Hopkins University
Template:Diseases of the musculoskeletal system and connective tissue
de:Sklerodermie it:Sclerodermia he:סקלרודרמה nl:Sclerodermie sk:Sklerodermia sv:Sklerodermi