ABCC1

ATP-binding cassette, sub-family C (CFTR/MRP), member 1
PDB rendering based on 2cbz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2cbz​
Identifiers
Symbols	ABCC1 ; MRP1; ABC29; ABCC; DKFZp686N04233; DKFZp781G125; GS-X; MRP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55459
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ATP-binding cassette, sub-family C (CFTR/MRP), member 1, also known as ABCC1, is a human gene.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

Further reading

• Lautier D, Canitrot Y, Deeley RG, Cole SP (1996). "Multidrug resistance mediated by the multidrug resistance protein (MRP) gene". Biochem. Pharmacol. 52 (7): 967–77. PMID 8831715.CS1 maint: Multiple names: authors list (link)
• Deeley RG, Cole SP (1998). "Function, evolution and structure of multidrug resistance protein (MRP)". Semin. Cancer Biol. 8 (3): 193–204. doi:10.1006/scbi.1997.0070. PMID 9441948.
• Hegedus T, Orfi L, Seprodi A; et al. (2002). "Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1". Biochim. Biophys. Acta. 1587 (2–3): 318–25. PMID 12084474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang XB (2007). "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1". Cancer Metastasis Rev. 26 (1): 15–37. doi:10.1007/s10555-007-9041-7. PMID 17295059.