ADCY8

Adenylate cyclase 8 (brain)
Identifiers
Symbols	ADCY8 ; ADCY3; HBAC1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37443
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Adenylate cyclase 8 (brain), also known as ADCY8, is a human gene.

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase

Further reading

• Stengel D, Parma J, Gannagé MH; et al. (1992). "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain". Hum. Genet. 90 (1–2): 126–30. PMID 1427768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parma J, Stengel D, Gannage MH; et al. (1991). "Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain". Biochem. Biophys. Res. Commun. 179 (1): 455–62. PMID 1715695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Defer N, Marinx O, Stengel D; et al. (1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Lett. 351 (1): 109–13. PMID 8076676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cali JJ, Zwaagstra JC, Mons N; et al. (1994). "Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain". J. Biol. Chem. 269 (16): 12190–5. PMID 8163524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu C, Cooper DM (1999). "Calmodulin-binding sites on adenylyl cyclase type VIII". J. Biol. Chem. 274 (12): 8012–21. PMID 10075700.
• Barcova M, Speth C, Kacani L; et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflugers Arch. 437 (4): 538–46. PMID 10089566.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. PMID 10807185.CS1 maint: Multiple names: authors list (link)
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. PMID 11299302.CS1 maint: Multiple names: authors list (link)
• Parkinson NA, Bolsover SR (2001). "A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones". Brain Res. Mol. Brain Res. 91 (1–2): 43–9. PMID 11457491.
• Speth C, Schabetsberger T, Mohsenipour I; et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". J. Virol. 76 (7): 3179–88. PMID 11884542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. PMID 12503609.
• Georget M, Mateo P, Vandecasteele G; et al. (2003). "Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8)". FASEB J. 17 (11): 1380–91. doi:10.1096/fj.02-0784com. PMID 12890691.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM (2006). "A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A". Mol. Pharmacol. 69 (2): 608–17. doi:10.1124/mol.105.018275. PMID 16258073.CS1 maint: Multiple names: authors list (link)
• Simpson RE, Ciruela A, Cooper DM (2006). "The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8". J. Biol. Chem. 281 (25): 17379–89. doi:10.1074/jbc.M510992200. PMID 16613843.CS1 maint: Multiple names: authors list (link)
• Nlend MC, Schmid A, Sutto Z; et al. (2007). "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Lett. 581 (17): 3241–6. doi:10.1016/j.febslet.2007.06.015. PMID 17586501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)