AFAP1

Actin filament associated protein 1
Identifiers
Symbols	AFAP1 ; AFAP; AFAP-110
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11009
Gene ontology
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Actin filament associated protein 1, also known as AFAP1, is a human gene.

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.

Further reading

• Baisden JM, Qian Y, Zot HM, Flynn DC (2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.CS1 maint: Multiple names: authors list (link)
• Ishida Y, Hadano S, Nagayama T; et al. (1995). "Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p". Genomics. 22 (2): 302–12. PMID 7545969.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qian Y, Baisden JM, Westin EH; et al. (1998). "Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity". Oncogene. 16 (17): 2185–95. doi:10.1038/sj.onc.1201753. PMID 9619827.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guappone AC, Weimer T, Flynn DC (1998). "Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif". Mol. Carcinog. 22 (2): 110–9. PMID 9655255.CS1 maint: Multiple names: authors list (link)
• Qian Y, Baisden JM, Zot HG; et al. (2000). "The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation". Exp. Cell Res. 255 (1): 102–13. doi:10.1006/excr.1999.4795. PMID 10666339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baisden JM, Gatesman AS, Cherezova L; et al. (2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qian Y, Baisden JM, Cherezova L; et al. (2003). "PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments". Mol. Biol. Cell. 13 (7): 2311–22. doi:10.1091/mbc.E01-12-0148. PMID 12134071.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qian Y, Gatesman AS, Baisden JM; et al. (2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J. Cell. Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dorfleutner A, Stehlik C, Zhang J; et al. (2007). "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells". J. Cell. Physiol. 213 (3): 740–9. doi:10.1002/jcp.21143. PMID 17520695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)