ALOX15B
| Arachidonate 15-lipoxygenase, type B | |||||||||||
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| Symbols | ALOX15B ; | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 886 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
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Arachidonate 15-lipoxygenase, type B, also known as ALOX15B, is a human gene.[1]
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.[1]
References
Further reading
- Sigal E, Grunberger D, Highland E; et al. (1990). "Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related". J. Biol. Chem. 265 (9): 5113–20. PMID 2318885.
- Brash AR, Boeglin WE, Chang MS (1997). "Discovery of a second 15S-lipoxygenase in humans". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6148–52. PMID 9177185.
- Kilty I, Logan A, Vickers PJ (2000). "Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase". Eur. J. Biochem. 266 (1): 83–93. PMID 10542053.
- Krieg P, Marks F, Fürstenberger G (2001). "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression". Genomics. 73 (3): 323–30. doi:10.1006/geno.2001.6519. PMID 11350124.
- Tang S, Bhatia B, Maldonado CJ; et al. (2002). "Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells". J. Biol. Chem. 277 (18): 16189–201. doi:10.1074/jbc.M111936200. PMID 11839751.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Xu XC, Shappell SB, Liang Z; et al. (2003). "Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398". Neoplasia. 5 (2): 121–7. PMID 12659684.
- Bhatia B, Maldonado CJ, Tang S; et al. (2003). "Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants". J. Biol. Chem. 278 (27): 25091–100. doi:10.1074/jbc.M301920200. PMID 12704195.
- Tang S, Bhatia B, Zhou J; et al. (2004). "Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells". Oncogene. 23 (41): 6942–53. doi:10.1038/sj.onc.1207913. PMID 15247906.
- Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Limor R, Kaplan M, Sawamura T; et al. (2005). "Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway". Am. J. Hypertens. 18 (3): 299–307. doi:10.1016/j.amjhyper.2004.09.008. PMID 15797645.
- Subbarayan V, Xu XC, Kim J; et al. (2005). "Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia". Neoplasia. 7 (3): 280–93. doi:10.1593/neo.04457. PMID 15799828.
- Jiang WG, Watkins G, Douglas-Jones A, Mansel RE (2006). "Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer". Prostaglandins Leukot. Essent. Fatty Acids. 74 (4): 235–45. doi:10.1016/j.plefa.2006.01.009. PMID 16556493.
- Subbarayan V, Krieg P, Hsi LC; et al. (2006). "15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma". Oncogene. 25 (44): 6015–25. doi:10.1038/sj.onc.1209617. PMID 16682954.
- Lesueur F, Bouadjar B, Lefèvre C; et al. (2007). "Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13". J. Invest. Dermatol. 127 (4): 829–34. doi:10.1038/sj.jid.5700640. PMID 17139268.
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